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This Concept Map, created with IHMC CmapTools, has information related to: Malignant Hyperthermia, RyR 1 gene mutation codes for RyR, Nick Thermopolis presenting with hyperthermia, increased anaerobic metabolism produces lactic acid, diagnostic studies show decreased PaCO2, diagnostic studies show elevated CK/CPK, Nick Thermopolis physical exam shows unconscious, body temp 42 degrees C suggests a high suspicion of Malignant Hyperthermia, Nick Thermopolis physical exam shows tachycardia, cellular acidosis causes decreased bicarbonate, increased aerobic metabolism increases CO2, Nick Thermopolis presenting with rigidity of jaw at intubation, diagnostic studies show hyperkalemia, Malignant Hyperthermia susceptibility comes from DHP gene mutation, Calcium causes initial muscle contraction, Malignant Hyperthermia confirmed by diagnostic studies, Malignant Hyperthermia susceptibility comes from RyR 1 gene mutation, sustained muscle contraction is an Exothermic Reaction, lactic acid adds to cellular acidosis, rhabdomyolysis causing myoglobinuria, DHP gene mutation which follows Autosomal Dominant Inheritance